Selank is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.
Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It has been shown to influence the concentration of monoamine neurotransmitters and induce metabolism of serotonin. There is evidence that it may also modulate the expression of brain-derived neurotropic factor (BDNF) in rats.
Selank, as well as a related peptide drug, semax, have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides, and this action may be involved in their effects.
While Selank is classified as a nootropic-anxiolytic type drug, it uses extend beyond the relief of anxiety and improved cognitive functioning alone. A few areas in which Selank may find itself useful are: Stress reduction, the alleviation of depression, reversal of anhedonia, improvement in mood in emotionally stable individuals,and cessation of insomnia. البته, with Selank being a nootropic-anxiolytic, it may also prove useful for the treatment of different forms of anxiety, such as G. A. D (generalized anxiety disorder), اس. A. D (social anxiety disorder), Panic Disorder, as well as non-diagnosed bouts of anxiety. As a nootropic, Selank can help enhance mental sharpness, reduce mental fatigue, improve the ability to focus, improve cognitive functioning while in a sleep deficit, and enhance memory.
These effects are provided without the negative side effects typically associated , such as physical dependence, psychological addiction, and decreased motor ability. در حقیقت, Selank is largely devoid of side effects, with the large majority of researchers claiming that it is a “side effect free” compound. This makes Selank more suitable for long-term use.