Эксенатида ацетат CAS:141758-74-9

Описание:

Пептид из 39 аминокислот, первоначально выделенный из слюнных желез монстра Гила. (Подозрение на Хелодерма.), отличается от эксендина-3 только в двух положениях, близких к N-концу. Применение эксенатида вызывает увеличение ацинарного цАМФ без стимуляции высвобождения амилазы.. Как инкретиновый миметик, Эксенатид действует как агонист глюкагоноподобного пептида-1. (ГЛП-1) рецептор. Как GLP-1, though with prolonged activity, Exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, Exenatide has found use as a medication of diabetes II.

заявка:

Exenatide is believed to facilitate glucose control in at least five ways:

1. Exenatide augments pancreas response and more appropriate amount of insulin that helps lower the rise in blood sugar from eating.

2. Exenatide also suppresses pancreatic release of glucagon, which prevents hyperglycemia (high blood sugar levels).

3. Exenatide helps slow down gastric emptying and thus decreases the rate at which meal-derived glucose appears in the bloodstream.

4. Exenatide has a subtle yet prolonged effect to reduce appetite, promote satiety via hypothalamic receptors.

5. Exenatide reduces liver fat content. Fat accumulation in the liver or nonalcoholic fatty liver disease (NAFLD) is strongly related with several metabolic disorders.