Гозерелина ацетат CAS:145781-92-6

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1. Гонадорелин — другое название гонадотропин-рилизинг-гормона. (ГнРГ). Это синтетический декапептид, полученный методом твердофазного пептидного синтеза.. ГнРГ отвечает за высвобождение фолликулостимулирующего гормона и лютинизирующего гормона из передней доли гипофиза..

2. ГнРГ доступен в виде гидрохлорида гонадорелина. )и тетрагидрат диацетата гонадорелина для инъекций. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.

3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.

The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, ГнРГ, controls a complex process of follicular growth, овуляция, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.