Dapoxetine CAS:119356-77-3

Det är en selektiv serotoninåterupptagshämmare (SSRI) som designades speciellt för för tidig utlösning. SSRI har visat sig vara effektiva för behandling av PE. Nackdelen med de flesta SSRI är att de måste tas dagligen för att uppnå önskad effekt. designades för att tas på en “efter behov” basis and has been shown to be effective when taken < 3 hours before sexual activity. Studies have shown that increases the intra-vaginal ejaculation latency time (IELTS) – the time from vaginal penetration to male orgasm.

Det är den första substansen som utvecklats speciellt för behandling av för tidig utlösning (PE) for men at th age of 18-64 år gammal. verkar genom att hämma serotonintransportören, ökar serotonins verkan vid den postsynaptiska klyftan, so as to delay ejaculation.. Som medlem av selektiv serotoninåterupptagshämmare (SSRI) familj, was initially created as an antidepressant. i alla fall, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.

Treat male premature ejaculation and erectile dysfunction.Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used. i alla fall, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, å andra sidan, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.