Trilostan är en hämmare av isoformerna 3β-HSD och 3β-HSD2 av enzymet 3β-hydroxisteroiddehydrogenas, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3∫-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Trilostane is used in the treatment of Cushing’s syndrome. It is normally used in short-term treatment …