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Fertirelina CAS:38234-21-8

Fertirelina
CAS Numarası.: 38234-21-8
Moleküler formül: C55H76N16O12
Moleküler ağırlık: 1153.29 g/mol
Saflık: 99%min
Dış görünüş: Beyaz toz
Seviye: Pharmaceutical grade

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Ürün Açıklaması:

Fertirelin is a synthetic luteinizing hormone-releasing hormone (LH-RH) analogue, and it is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fertirelin was administered at the beginning of the protocol followed 7 days later by 500 μ G cloprosterol. Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus. The conception rate did not differ between the 50 μ G fertirelin group (61.1%; N = 72) and the 100 μ G group.

Applications:

Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is:

1. So that the body arteriole smooth muscle contraction, increased peripheral resistance;

2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume;

3. Directly contribute to renal tubular sodium and water reabsorption;

4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance;

5. Stimulate the adrenal medulla to release epinephrine and norepinephrine.

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